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Peptide record

TPDB61947

hsMPG Cell-penetrating Peptides standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB61947
hsMPG
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 27-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
GALFLGFLGAAGSTMGAWSQPHHHHHV
Physicochemical Analysis
C129H183N39O32S1
RNDCEIKY
GH
2824.17
8.20
5
0
12
+0
-0.35
0.148
68.89
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
194.75
4
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
0
E
1
Q
5
G
5
H
0
I
3
L
0
K
1
M
2
F
1
P
2
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 5 H: 5 I: 0 L: 3 K: 0 M: 1 F: 2 P: 1 S: 2 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
27
C129H183N39O32S1
2824.17
8.20
+0
-0.35
0.148
Free
L
Linear
Free
N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Freestyletm 293-F Cells And Red Blood Cell Membranes

Assay & Model

BALB/c nude mice
BALB/c nude mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Increased membrane perturbation activity at pH 6.0 (early endosome pH) and pH 5.5 (late endosome pH).
In vitro and in vivo
CCCCCSSSSSCC
Additional Detail Fields 1 fields
CCCCCSSSSSCC