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Peptide record

TPDB61945

MPGα Cell-penetrating Peptides standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB61945
MPGα
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 27-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
C-terminal: Cysteamide group N-terminal: Acetylation
Sequence
Ac-GALFLAFLAAALSLMGLWSQPKKKRKV
Physicochemical Analysis
C140H230N36O31S1
NDCEHITY
L
2945.65
11.80
5
0
16
+5
-2.40
0.556
115.93
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
186.72
3
Residue Composition
number
5
A
1
R
0
N
0
D
0
C
0
E
1
Q
2
G
0
H
0
I
6
L
4
K
1
M
2
F
1
P
2
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 5 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 2 H: 0 I: 0 L: 6 K: 4 M: 1 F: 2 P: 1 S: 2 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
27
C140H230N36O31S1
2945.65
11.80
+5
-2.40
0.556
Cysteamide group
L
Cationic
Linear
Acetylation
NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, COS-7, NIH-3T3, Jurkat, NB-4, Kasumi-1, Leishmania tarentolae cell line

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Protein (ATTO488-BSA, ?-galactosidase)
Nucleus
In vitro
CCCCHHHHHHHIIIIISTTCCCSSCCC
Additional Detail Fields 1 fields
CCCCHHHHHHHIIIIISTTCCCSSCCC