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Peptide record

TPDB61937

DCpep Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB61937
DCpep
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: GFP
Sequence
FYPSYHSTPQRP
Physicochemical Analysis
C69H94N18O19
ANDCEGILKMWV
P
1479.61
9.63
2
0
3
+1
1.09
-1.508
0.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
2980
201.40
6
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
1
Q
0
G
1
H
0
I
0
L
0
K
0
M
1
F
3
P
2
S
1
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 1 P: 3 S: 2 T: 1 W: 0 Y: 2 V: 0
Chemical Descriptors
12
C69H94N18O19
1479.61
9.63
+1
1.09
-1.508
Free
L
Linear
GFP
N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Jurkat Cell, Bcbl1, Macrophage Cells (Mø), Mast Cells And Non-Immune Modulatory Cells,293T , Panc-1 And Hpde Cells

Assay & Model

Eight-week-old female C57BL/6 mice
Eight-week-old female C57BL/6 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Phage Display
GFP protein
DCpep-GFP was not observed in any other cell type (0%) except in dendritic cells
In vitro and in vivo
CCSSSCCSCCC
Additional Detail Fields 1 fields
CCSSSCCSCCC