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Peptide record

TPDB61921

hsPen Cell-penetrating Peptides standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB61921
hsPen
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 27-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
FSGSGSGSGHQIHIWFQNHHMHWHHGC
Physicochemical Analysis
C138H182N46O35S2
ARDELKPTYV
H
3109.37
7.61
7
0
7
+1
1.82
-0.774
28.89
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
11000
353.77
8
Residue Composition
number
0
A
0
R
1
N
0
D
1
C
0
E
2
Q
5
G
7
H
2
I
0
L
0
K
1
M
2
F
0
P
4
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 1 E: 0 Q: 2 G: 5 H: 7 I: 2 L: 0 K: 0 M: 1 F: 2 P: 0 S: 4 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
27
C138H182N46O35S2
3109.37
7.61
+1
1.82
-0.774
Free
L
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Freestyletm 293-F Cells And Red Blood Cell Membranes

Assay & Model

BALB/c nude mice
BALB/c nude mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Increased membrane perturbation activity at pH 6.0 (early endosome pH) and pH 5.5 (late endosome pH).
In vitro and in vivo
CCSSSCCCCCSCCSSSCSSHHHHCCTTC
Additional Detail Fields 1 fields
CCSSSCCCCCSCCSSSCSSHHHHCCTTC