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Peptide record

TPDB61920

hsTP10 Cell-penetrating Peptides standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB61920
hsTP10
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 32-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
FSGSGSGSGAGYLLGHINLHALAALAHHILGC
Physicochemical Analysis
C138H213N41O39S1
RDEQKMPTWV
G
3102.52
7.47
4
0
15
+0
-2.29
0.703
113.13
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
1490
48.03
7
Residue Composition
number
5
A
0
R
1
N
0
D
1
C
0
E
0
Q
7
G
4
H
2
I
6
L
0
K
0
M
1
F
0
P
4
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 5 R: 0 N: 1 D: 0 C: 1 E: 0 Q: 0 G: 7 H: 4 I: 2 L: 6 K: 0 M: 0 F: 1 P: 0 S: 4 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
32
C138H213N41O39S1
3102.52
7.47
+0
-2.29
0.703
Free
L
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Freestyletm 293-F Cells And Red Blood Cell Membranes

Assay & Model

BALB/c nude mice
BALB/c nude mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Increased membrane perturbation activity at pH 6.0 (early endosome pH) and pH 5.5 (late endosome pH).
In vitro and in vivo
CCSCC
Additional Detail Fields 1 fields
CCSCC