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Peptide record

TPDB61915

NLS-α-CE TAMRA-NLS-α-CE Cell-penetrating Peptides standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB61915
NLS-α-CE TAMRA-NLS-α-CE
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 35-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with TAMRA
Sequence
FRKWRRKPKKKRKVWWRKVKRRWHWLQLKPGQPMY
Physicochemical Analysis
C229H358N74O39S1
ANDCEIST
K
4803.89
12.81
17
0
12
+16
5.53
-1.917
38.86
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
28990
603.47
3
Residue Composition
number
0
A
7
R
0
N
0
D
0
C
0
E
2
Q
1
G
1
H
0
I
2
L
9
K
1
M
1
F
3
P
0
S
0
T
5
W
1
Y
2
V
Amino Acid Distribution
A: 0 R: 7 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 1 H: 1 I: 0 L: 2 K: 9 M: 1 F: 1 P: 3 S: 0 T: 0 W: 5 Y: 1 V: 2
Chemical Descriptors
35
C229H358N74O39S1
4803.89
12.81
+16
5.53
-1.917
Free
L
Linear
Conjugated with TAMRA
N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

S. Cerevisiae (Mata And Matα ), Hek293T , Hek293T-Nep And HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
TAMRA dye
NLS-α-CE and chimera peptides penetrate less efficiently MATa cells than the α-NLS-C
In vitro
CCCCGGGCSSSCGGGCCCGGGGSCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Yeast cells and Primary Mouse Embryo Fibroblasts (MEFs)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
TAMRA dye
Nuclear
In vitro
CCCCCCC
Additional Detail Fields 1 fields
CCCCGGGCSSSCGGGCCCGGGGSCCC CCCCCCC