Back to search

Peptide record

TPDB61913

MPP Cell-penetrating Peptides standard
4 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB61913
MPP
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 4-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with CHOlesterol
Sequence
FRFK
Physicochemical Analysis
C30H44N8O5
ANDCEQGHILMPSTWYV
F
596.73
11.49
2
0
2
+2
-0.46
-0.700
0.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
4
C30H44N8O5
596.73
11.49
+2
-0.46
-0.700
Free
L
Linear
Conjugated with CHOlesterol
N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A549 Cell

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Antimycin A (AMA) and Carboxyfluorescein (CF)-labeled liposomes
Mitochondria
Fluorescence of CHOl-FRFK/D liposome treated cells was higher compared with that of DQAsomes and D/D liposomes.
In vitro
CCSSCSSCC
Additional Detail Fields 1 fields
CCSSCSSCC