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Peptide record

TPDB61909

CPP (Dex-2) Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB61909
CPP (Dex-2)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Alexa 488 labelling N-terminal: Amidation
Sequence
FNLPLPSRPLLR
Physicochemical Analysis
C67H111N19O15
ADCEQGHIKMTWYV
L
1422.74
12.40
2
0
5
+2
0.15
-0.008
130.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
0
A
2
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
4
L
0
K
0
M
1
F
3
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 0 M: 0 F: 1 P: 3 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C67H111N19O15
1422.74
12.40
+2
0.15
-0.008
Free
Alexa 488 labelling
L
Linear
Amidation
NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

ARPE-19 Cells

Assay & Model

Pigmented 2.5–3.0 kg female Dutch belted rabbits
Pigmented 2.5–3.0 kg female Dutch belted rabbits

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Dexamethasone via cleavable peptide-based linker (PCL)
Conjugates were internalized within the ARPE-19 cells without association at the cell surface
In vitro and in vivo
CCCCCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCCCCC