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Peptide record

TPDB61908

L2 Cell-penetrating Peptides standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB61908
L2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 28-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugated with CF
Sequence
FLLIRRVLGSTSRDHMVLHEYVNAAGIT-NH2
Physicochemical Analysis
C141H230N42O39S1
CQKPW
L
3169.70
9.87
5
2
14
+1
3.29
0.343
121.79
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
1490
47.01
6
Residue Composition
number
2
A
3
R
1
N
1
D
0
C
1
E
0
Q
2
G
2
H
2
I
4
L
0
K
1
M
1
F
0
P
2
S
2
T
0
W
1
Y
3
V
Amino Acid Distribution
A: 2 R: 3 N: 1 D: 1 C: 0 E: 1 Q: 0 G: 2 H: 2 I: 2 L: 4 K: 0 M: 1 F: 1 P: 0 S: 2 T: 2 W: 0 Y: 1 V: 3
Chemical Descriptors
28
C141H230N42O39S1
3169.70
9.87
+1
3.29
0.343
Amidation
L
Hydrophobic
Linear
Conjugated with CF
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, Hek293T, Jurkat E6.1 Leukemia Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Hydrophobic
Synthetic
carboxyfluorescein(CF) dye
Cytoplasm
In vitro
CCCCCSCCTTCC
Additional Detail Fields 1 fields
CCCCCSCCTTCC