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Peptide record

TPDB61903

M 511 Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB61903
M 511
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 15-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugation with fluorescein
Sequence
FLGKKFKKYFLQLLK-NH2
Physicochemical Analysis
C97H153N21O18
ARNDCEHIMPSTWV
K
1901.41
10.77
5
0
8
+5
-1.03
-0.073
104.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
1490
78.36
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
0
I
4
L
5
K
0
M
3
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 4 K: 5 M: 0 F: 3 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
15
C97H153N21O18
1901.41
10.77
+5
-1.03
-0.073
Amidation
L
Linear
Conjugation with fluorescein
N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Human SH-SY5Y, N2A and Human bowes melanoma cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Fluorophore (fluorescein)
Higher than penetratin
In vitro
CTTHHHHHHHHHTCC
Additional Detail Fields 1 fields
CTTHHHHHHHHHTCC