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Peptide record

TPDB61895

T2 Cell-penetrating Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB61895
T2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 9-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
FKKFFRKLL-NH2
Physicochemical Analysis
C63H99N15O10
ANDCEQGHIMPSTWYV
KF
1226.57
11.73
4
0
5
+4
-0.73
-0.022
86.67
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
3
K
0
M
3
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 3 M: 0 F: 3 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C63H99N15O10
1226.57
11.73
+4
-0.73
-0.022
Amidation
L
Amphipathic
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Cancer Cells (MCF-7, HeLa, Ht-29, A2780, A2780/Ptx) And Normal Cells (Ncm460, Hek-293).

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
5-carboxyfluorescein (5-FAM) and cysteine at C-terminal
Cytoplasm
T2 in which Lys9 was substituted to Leu exhibited more favorable permeability than others and control(R9)
In vitro
CGGGGGGTC
Additional Detail Fields 1 fields
CGGGGGGTC