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Peptide record

TPDB61888

Tat (37-60) Cell-penetrating Peptides standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB61888
Tat (37-60)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 Peptipedia
standard
No
A 23-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, and Peptipedia, with an available 3D structural model.
C-terminal: Conjugation with fluorescein maleimide N-terminal: Labelled with Cys-acetamidomethyl
Sequence
FITKALGISYGRKKRRQRRRPPQ
Physicochemical Analysis
C124H214N46O29
NDCEHMWV
R
2813.35
12.71
9
0
6
+9
6.76
-1.526
55.22
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
1490
52.96
5
Residue Composition
number
1
A
6
R
0
N
0
D
0
C
0
E
2
Q
2
G
0
H
2
I
1
L
3
K
0
M
1
F
2
P
1
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 2 H: 0 I: 2 L: 1 K: 3 M: 0 F: 1 P: 2 S: 1 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
23
C124H214N46O29
2813.35
12.71
+9
6.76
-1.526
Conjugation with fluorescein maleimide
L
Cationic
Linear
Labelled with Cys-acetamidomethyl
N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Fluorophore (fluorescein)
Cytoplasm and nucleus, nucelolus
High
Non-endocytic mechanism
In vitro
CCCCCCSCCTTBTTTBSCSSCCC
Additional Detail Fields 1 fields
CCCCCCSCCTTBTTTBSCSSCCC