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Peptide record

TPDB61887

Tat (37-53) Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB61887
Tat (37-53)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 Peptipedia
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, and Peptipedia, with an available 3D structural model.
C-terminal: Conjugation with fluorescein maleimide N-terminal: Labelled with Cys-acetamidomethyl
Sequence
FITKALGISYGRKKRR
Physicochemical Analysis
C86H148N28O20
NDCEQHMPWV
RK
1894.30
12.15
6
0
6
+6
2.27
-0.713
79.38
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
1490
78.66
3
Residue Composition
number
1
A
3
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
2
I
1
L
3
K
0
M
1
F
0
P
1
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 1 K: 3 M: 0 F: 1 P: 0 S: 1 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
16
C86H148N28O20
1894.30
12.15
+6
2.27
-0.713
Conjugation with fluorescein maleimide
L
Cationic
Linear
Labelled with Cys-acetamidomethyl
N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Fluorophore (fluorescein)
Cytoplasm and nucleus, nucelolus
Low
Non-endocytic mechanism
In vitro
CCTTSSCEETTTTEEC
Additional Detail Fields 1 fields
CCTTSSCEETTTTEEC