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Peptide record

TPDB61880

CPP1 Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB61880
CPP1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: IR780-labeled usNLCs
Sequence
FGWKWLKWLK-NH2
Physicochemical Analysis
C74H102N16O11
ARNDCEQHIMPSTYV
KW
1391.72
10.84
3
0
6
+3
-4.82
-0.440
78.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
16500
1185.58
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
2
L
3
K
0
M
1
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 3 M: 0 F: 1 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
10
C74H102N16O11
1391.72
10.84
+3
-4.82
-0.440
Amidation
IR780-labeled usNLCs
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hbmec Cell Monolayer And U87 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Celecoxib (CXB)
Uptake across the BBB = CPP4 > CPP2 >CPP3 > CPP5 > c(RGDfK) > CPP1. CPP1, CPP2, CPP3, CPP5, and c(RGDfK) demonstrated higher uptake efficiency in the U87 cell membrane.
Non-dependent energy pathway (e.g., direct translocation).
In vitro and ex vivo
CCCCCCGGGCCSSCCCCC
Additional Detail Fields 1 fields
CCCCCCGGGCCSSCCCCC