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Peptide record

TPDB61877

2F-RT Cell-penetrating Peptides standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB61877
2F-RT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 22-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
FFRADARADAGRKKRRQRRRPQ-NH2
Physicochemical Analysis
C115H196N50O29
NCEHILMSTWYV
R
2743.14
12.63
10
2
6
+8
9.60
-2.136
18.18
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
4
A
8
R
0
N
2
D
0
C
0
E
2
Q
1
G
0
H
0
I
0
L
2
K
0
M
2
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 8 N: 0 D: 2 C: 0 E: 0 Q: 2 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 2 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
22
C115H196N50O29
2743.14
12.63
+8
9.60
-2.136
Amidation
L
Cationic
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells Andf Mef-P62-Luc Cells

Assay & Model

C57BL/6J mice (12 weeks old)
C57BL/6J mice (12 weeks old)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Cy-7 labelled and Rapamycin
Internalization of Cy-7 labelled 2F-RT display within 3 hours of exposure
In vitro and in vivo
CCCTTTTCTTCSTTTTSSSSCC
Additional Detail Fields 1 fields
CCCTTTTCTTCSTTTTSSSSCC