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Peptide record

TPDB61874

PASR8-NMU Cell-penetrating Peptides standard
40 amino acids
Basic Information
3D PDB MODEL
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TPDB61874
PASR8-NMU
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 40-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
FFLIPKGRRRRRRRRGGYKVNEYQGPVAPSGGFFLFRPRN
Physicochemical Analysis
C219H343N75O49
DCHMTW
R
4810.61
12.58
12
1
13
+11
6.52
-1.067
46.25
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
2980
61.95
6
Residue Composition
number
1
A
10
R
2
N
0
D
0
C
1
E
1
Q
6
G
0
H
1
I
2
L
2
K
0
M
5
F
4
P
1
S
0
T
0
W
2
Y
2
V
Amino Acid Distribution
A: 1 R: 10 N: 2 D: 0 C: 0 E: 1 Q: 1 G: 6 H: 0 I: 1 L: 2 K: 2 M: 0 F: 5 P: 4 S: 1 T: 0 W: 0 Y: 2 V: 2
Chemical Descriptors
40
C219H343N75O49
4810.61
12.58
+11
6.52
-1.067
Free
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Assay & Model

5- to 7-week-old male ddY mice
5- to 7-week-old male ddY mice

Source & Reference

CPPsite3.0
CPPsite3
WO 2016/035820 A1 USA: 15/507, 403 EU: 15837573.3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Neuromedin U (NMU) , indocyanine green (ICG)
Nucleus
ICG-labeled PASR8-NMU group exhibited denser fluorescence than the vehicle group in the hippocampus
In vivo
CCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCC