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Peptide record

TPDB61871

PasR8 (Alexa) PasR8-p27kip1C PasR8-PAD Blood-Brain Barrier Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB61871
PasR8 (Alexa) PasR8-p27kip1C PasR8-PAD
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
BBPpredict CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 17-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from BBPpredict, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
FFLIPKGRRRRRRRRGC-NH2
Physicochemical Analysis
C96H168N42O18S1
ANDEQHMSTWYV
R
2230.72
12.88
9
0
4
+9
4.57
-1.524
45.88
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
8
R
0
N
0
D
1
C
0
E
0
Q
2
G
0
H
1
I
1
L
1
K
0
M
2
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 8 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 1 K: 1 M: 0 F: 2 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
17
C96H168N42O18S1
2230.72
12.88
+9
4.57
-1.524
Amidation
L
Cationic
Linear
N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CS)C(=O)O
Evidence Records 3 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, T98G glioma cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Fluorophore (Alexa)
Cytosol
PasR8(Alexa) efficiently internalizes into cells a few minutes after peptide administration
Macropinocytosis
In vitro
CCSCGGGTTTTGGGSCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, T98G glioma cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
Peptide (cyclin-dependent kinase inhibitor)
Cytosol
In vitro
CCSCGGGTTTTGGGSCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, T98G glioma cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
Peptide [(Proapoptotic domain (PAD)]
Cytosol
In vitro
CCSCGGGTTTTGGGSCC
Additional Detail Fields 1 fields
CCSCGGGTTTTGGGSCC