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Peptide record

TPDB61863

F2R8 (Alexa) Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB61863
F2R8 (Alexa)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 Peptipedia
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, and Peptipedia, with an available 3D structural model.
C-terminal: Amidation
Sequence
FFGRRRRRRRGC-NH2
Physicochemical Analysis
C67H115N33O13S1
ANDEQHILKMPSTWYV
R
1622.92
12.80
7
0
2
+7
3.19
-2.017
0.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
7
R
0
N
0
D
1
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 7 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C67H115N33O13S1
1622.92
12.80
+7
3.19
-2.017
Amidation
L
Cationic
Linear
N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, T98G glioma cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Fluorophore (Alexa)
Cytosol
Uptake was less compared to PasR8 but higher than LILIR8
In vitro
CTTTCGGGGSCC
Additional Detail Fields 1 fields
CTTTCGGGGSCC