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Peptide record

TPDB61831

BBA-CPP9 (peptide 23) Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB61831
BBA-CPP9 (peptide 23)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Conjugated with FAM via MiniPEG-Lys Linker N-terminal: Acetylation
Sequence
Ac-ETFCHYWCQLTS
Physicochemical Analysis
C68H92N16O20S2
ARNDGIKMPV
CT
1517.69
5.13
1
1
4
-1
-0.99
-0.250
32.50
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
7115
468.80
7
Residue Composition
number
0
A
0
R
0
N
0
D
2
C
1
E
1
Q
0
G
1
H
0
I
1
L
0
K
0
M
1
F
0
P
1
S
2
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 2 E: 1 Q: 1 G: 0 H: 1 I: 0 L: 1 K: 0 M: 0 F: 1 P: 0 S: 1 T: 2 W: 1 Y: 1 V: 0
Chemical Descriptors
12
C68H92N16O20S2
1517.69
5.13
-1
-0.99
-0.250
Conjugated with FAM via MiniPEG-Lys Linker
L
Linear
Acetylation
N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Sjsa-1 Cells, HeLa Cells , Sw480 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
FAM dye
Cytoplasm and nucleus
Cells treated with peptides 21, 23, or 25 were brightly fluorescent, showing a combination of punctate and diffuse fluorescence signals in HeLa cells and with the latter being throughout the entire cell volume including the nucleus.
In vitro
CCSSCCCCTTC
Additional Detail Fields 1 fields
CCSSCCCCTTC