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Peptide record

TPDB61828

H1 Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB61828
H1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 15-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
ERQAREHSERKKRRR
Physicochemical Analysis
C80H144N38O24
NDCGILMFPTWYV
R
2022.26
12.12
9
3
1
+5
14.40
-3.400
6.67
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
0
0.00
2
Residue Composition
number
1
A
6
R
0
N
0
D
0
C
3
E
1
Q
0
G
1
H
0
I
0
L
2
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 6 N: 0 D: 0 C: 0 E: 3 Q: 1 G: 0 H: 1 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
15
C80H144N38O24
2022.26
12.12
+5
14.40
-3.400
Free
L
Linear
Free
N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
EGFP protein
Cytoplasm and nucleus
EGFP-H3 and EGFP-H4 showed higher cellular uptake than that of EGFP-HBD, EGFP-H1 and EGFP-H2
In vitro
CCCSSSSTTTTTCC
Additional Detail Fields 1 fields
CCCSSSSTTTTTCC