Back to search

Peptide record

TPDB61825

NF-YAl Cell-penetrating Peptides standard
59 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB61825
NF-YAl
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 59-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
EPLYVNAKQYHRILKRRQARAKLEAEGKIPKERRKYLHESRHRHAMARKRGEGGRFFSP
Physicochemical Analysis
C314H512N110O80S1
DCTW
R
7140.27
11.62
22
6
19
+12
25.91
-1.463
54.75
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
4470
62.60
8
Residue Composition
number
6
A
11
R
1
N
0
D
0
C
6
E
2
Q
4
G
4
H
2
I
4
L
7
K
1
M
2
F
3
P
2
S
0
T
0
W
3
Y
1
V
Amino Acid Distribution
A: 6 R: 11 N: 1 D: 0 C: 0 E: 6 Q: 2 G: 4 H: 4 I: 2 L: 4 K: 7 M: 1 F: 2 P: 3 S: 2 T: 0 W: 0 Y: 3 V: 1
Chemical Descriptors
59
C314H512N110O80S1
7140.27
11.62
+12
25.91
-1.463
Free
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Human HCT-116 And Mouse Myoblast Cells (C2C12)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
NF-YA subunit of the heterotrimeric transcription factor NF-Y
Cytoplasm(Less) And Nucleus(More)
NF-YAl enters cells at nanomolar concentrations. NF-YAl entered HCT116 cells but not YAm23-34 and YAm23-33. Efficient entry of TRX-NF-YAl was recorded, similar to the one shown for NF-YAl produced in in HCT116 and in HeLa cells.
In vitro
CCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCC