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Peptide record

TPDB61821

YAm32 Cell-penetrating Peptides standard
59 amino acids
Basic Information
3D PDB MODEL
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TPDB61821
YAm32
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 59-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
EPLYVNAKQYHRILKRRQARAKLEAEGKIPKEAAAYLHESRHRHAMARKRGEGGRFFSP
Physicochemical Analysis
C305H491N103O80S1
DCTW
AR
6912.96
11.12
19
6
22
+9
22.79
-1.153
59.83
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
4470
64.66
8
Residue Composition
number
9
A
9
R
1
N
0
D
0
C
6
E
2
Q
4
G
4
H
2
I
4
L
6
K
1
M
2
F
3
P
2
S
0
T
0
W
3
Y
1
V
Amino Acid Distribution
A: 9 R: 9 N: 1 D: 0 C: 0 E: 6 Q: 2 G: 4 H: 4 I: 2 L: 4 K: 6 M: 1 F: 2 P: 3 S: 2 T: 0 W: 0 Y: 3 V: 1
Chemical Descriptors
59
C305H491N103O80S1
6912.96
11.12
+9
22.79
-1.153
Free
L
Linear
Free
N[C@@H](CCC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Human HCT-116 And Mouse Myoblast Cells (C2C12)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
NF-YA subunit of the heterotrimeric transcription factor NF-Y
Cytoplasm(Less) And Nucleus(More)
YAm32 and YAm33 were only to some extent reduced in nuclear extracts with respect to wt NF-YA in HCT116 cells
In vitro
CCSSSSTTTSSHHHHHHHHHHHTTTTSSCCGGGCCSSCSCSSSCCSSSSSSCCCC
Additional Detail Fields 1 fields
CCSSSSTTTSSHHHHHHHHHHHTTTTSSCCGGGCCSSCSCSSSCCSSSSSSCCCC