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Peptide record

TPDB61813

CC12-FITC Cell-penetrating Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB61813
CC12-FITC
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 13-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Conjugated with FITC
Sequence
EMFTPPSMIERLK
Physicochemical Analysis
C70H115N17O20S2
ANDCQGHWYV
EMP
1578.91
7.09
2
2
5
+0
4.55
-0.400
60.00
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
2
E
0
Q
0
G
0
H
1
I
1
L
1
K
2
M
1
F
2
P
1
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 2 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 1 M: 2 F: 1 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C70H115N17O20S2
1578.91
7.09
+0
4.55
-0.400
Conjugated with FITC
L
Amphiphilic
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Human Retinal Pigment Epithelial Cell Line (ARPE-19)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L Amphiphilic
Synthetic
FITC-conjugated
Lysosomes and Cytosol
Chlorpromazine, wortmannin, cytochalasin D and oligomycin had significant dose-dependent inhibitory effects on the cell uptake of CC12 peptides, while the dose-dependent effect of nystatin was not significant
Clathrin and caveolae mediated endocytosis
In vitro