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Peptide record

TPDB61812

CC12-KV11 Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB61812
CC12-KV11
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Conjugated with FITC
Sequence
EMFTPPSMIERL
Physicochemical Analysis
C64H103N15O19S2
ANDCQGHKWYV
EMP
1450.73
4.26
1
2
5
-1
3.56
-0.108
65.00
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
2
E
0
Q
0
G
0
H
1
I
1
L
0
K
2
M
1
F
2
P
1
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 2 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 0 M: 2 F: 1 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C64H103N15O19S2
1450.73
4.26
-1
3.56
-0.108
Conjugated with FITC
L
Linear
Free
N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

ARPE-19 And HUVECs Rabbit (Adult Albino Rabbits (2.5 Kg)) Cornea And Sclera-CHOroid-Retina Complexes

Assay & Model

Male Sprague-Dawley rats (0.15 kg), neonatal C57BL/6J mice with mothers
Male Sprague-Dawley rats (0.15 kg), neonatal C57BL/6J mice with mothers

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Phage Display
KV11 peptide via glycine (-GGG-) residues
At 4 h, 50 μM of CC12-KV11-FITC peptide displayed an average fluorescence higher than untreated cells and of the cells treated with KV11-FITC.
In-vitro, in-vivo and ex vivo
CCSCCCHHHHTC
Additional Detail Fields 1 fields
CCSCCCHHHHTC