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Peptide record

TPDB61794

desPyr-BPP13a Cell-penetrating Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB61794
desPyr-BPP13a
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 13-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: desPyroglutamic acid (E)
Sequence
EGGWPRPGPEIPP
Physicochemical Analysis
C64H93N17O18
ANDCQHLKMFSTYV
P
1388.55
4.26
1
2
2
-1
4.97
-1.315
30.00
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
5500
396.10
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
2
E
0
Q
3
G
0
H
1
I
0
L
0
K
0
M
0
F
5
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 2 Q: 0 G: 3 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 5 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
13
C64H93N17O18
1388.55
4.26
-1
4.97
-1.315
Free
L
Linear
desPyroglutamic acid (E)
N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HDFa, SK-MEL-28 and A2058 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
AlexaFluor® 488 dye
Perinuclear
Able to penetrate both tumor cell lines after 30 min
In vitro and in vivo
CCCSHHHHHHHHHCC
Additional Detail Fields 1 fields
CCCSHHHHHHHHHCC