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Peptide record

TPDB61790

BBBpS_3 Cell-penetrating Peptides standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB61790
BBBpS_3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 18-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugated with CF
Sequence
EEGRLYMRYYSPTTRRYG-NH2
Physicochemical Analysis
C101H152N30O30S1
ANDCQHIKFWV
RY
2298.56
9.81
4
2
6
+2
3.61
-1.617
21.67
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
5960
259.29
7
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
2
E
0
Q
2
G
0
H
0
I
1
L
0
K
1
M
0
F
1
P
1
S
2
T
0
W
4
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 2 Q: 0 G: 2 H: 0 I: 0 L: 1 K: 0 M: 1 F: 0 P: 1 S: 1 T: 2 W: 0 Y: 4 V: 0
Chemical Descriptors
18
C101H152N30O30S1
2298.56
9.81
+2
3.61
-1.617
Amidation
L
Hydrophobic
Linear
Conjugated with CF
N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hebc-5I, Hs68, HeLa, MDA-MB-231 And Hek-293 Cells

Assay & Model

7-weeks old CD1 female mice
7-weeks old CD1 female mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Hydrophobic
Synthetic
CF dye and Ga-radiolabed for in-vivo
Translocation = 35.7 ± 3.6
In vitro and in vivo
CCCCSSCCSCC
Additional Detail Fields 1 fields
CCCCSSCCSCC