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Peptide record

TPDB61788

E3-MP(Dpa) Cell-penetrating Peptides modified_plain modified
17 amino acids
Basic Information
3D PDB MODEL
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TPDB61788
E3-MP(Dpa)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 17-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: Alexa Fluor 488 via an appended C-terminal Gly-Gly-Cys linker were
Sequence
EEEINWXGIAAJAKKLL-NH2
Physicochemical Analysis
C77H125N19O23
RDCQHMFPSTYV
AE
1684.95
4.55
2
3
8
-1
4.37
-0.065
109.41
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
5500
326.42
1
Residue Composition
number
3
A
0
R
1
N
0
D
0
C
3
E
0
Q
1
G
0
H
2
I
2
L
2
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 0 C: 0 E: 3 Q: 0 G: 1 H: 0 I: 2 L: 2 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
17
C77H125N19O23
1684.95
4.55
-1
4.37
-0.065
Amidation
Alexa Fluor 488 via an appended C-terminal Gly-Gly-Cys linker were
Modified
Cationic and amphiphilic
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear Modified Cationic and amphiphilic
Synthetic
FITC-dextran
Cytosol
Nickel was found to be the best for enhancing E3-MP(Dpa)-Alexa internalisation circa 17- and circa 6-fold higher cellular uptake were observed compared to E3-MP-Alexa and E3-MP(Dpa)-Alexa without metal complex conjugation, respectively
Endocytosis
In vitro