Back to search

Peptide record

TPDB61785

ACPP Cell-penetrating Peptides standard
23 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB61785
ACPP
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 23-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, Peptipedia, and PerseuCPP, with an available 3D structural model.
Sequence
EEEEEEEEPLGLAGRRRRRRRRN
Physicochemical Analysis
C116H200N48O41
DCQHIKMFSTWYV
RE
2923.16
7.42
8
8
3
+0
22.24
-2.630
38.26
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
1
A
8
R
1
N
0
D
0
C
8
E
0
Q
2
G
0
H
0
I
2
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 8 N: 1 D: 0 C: 0 E: 8 Q: 0 G: 2 H: 0 I: 0 L: 2 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
23
C116H200N48O41
2923.16
7.42
+0
22.24
-2.630
Free
L
Linear
Free
N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A549, MDA-MB-231, Human bronchial epithelial (HBE) cells and HepG2 and Recombinant Ad5 viruses

Assay & Model

Male and female bufo gargarizans and male and female Sprague-Dawley(SD) rats
Male and female bufo gargarizans and male and female Sprague-Dawley(SD) rats

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
ACPP-HPMA Copolymer-Coated Adenovirus Conjugates
Cytoplasm
Higher uptake efficiency
Endocytotic process
In vitro and in vivo
CCCCCCTTTCCSSSTTSSSSCCC
Additional Detail Fields 1 fields
CCCCCCTTTCCSSSTTSSSSCCC