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Peptide record

TPDB61782

ACPP Cell-penetrating Peptides standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB61782
ACPP
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 25-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
EEEEEEEEEAPLGAGCRRRRRRRRR-NH2
Physicochemical Analysis
C123H212N52O44S1
NDQHIKMFSTWYV
RE
3155.42
6.76
9
9
3
-0
24.80
-2.580
23.60
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
2
A
9
R
0
N
0
D
1
C
9
E
0
Q
2
G
0
H
0
I
1
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 9 N: 0 D: 0 C: 1 E: 9 Q: 0 G: 2 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
25
C123H212N52O44S1
3155.42
6.76
-0
24.80
-2.580
Amidation
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Ht-1080, Hmec-1, Bt-474, MDA-MB231

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Near-infrared fluorescent DY676 labelled
Fluorescence in ACPP-DY676 treated cells is a result of activation and internalization
In vitro
CCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCC