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Peptide record

TPDB61768

C45D18 Cell-penetrating Peptides standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB61768
C45D18
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 22-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, Peptipedia, and other sources, with an available 3D structural model.
C-terminal: Conjugation with nanoparticle
Sequence
DTWAGVEAIIRILQQLLFIHFR
Physicochemical Analysis
C125H195N33O30
NCKMPSY
I
2640.13
7.85
3
2
13
+0
-0.16
0.664
146.36
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
5500
208.32
3
Residue Composition
number
2
A
2
R
0
N
1
D
0
C
1
E
2
Q
1
G
1
H
4
I
3
L
0
K
0
M
2
F
0
P
0
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 2 N: 0 D: 1 C: 0 E: 1 Q: 2 G: 1 H: 1 I: 4 L: 3 K: 0 M: 0 F: 2 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
22
C125H195N33O30
2640.13
7.85
+0
-0.16
0.664
Conjugation with nanoparticle
L
Linear
Free
N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa

Source & Reference

CPPsite3.0
CPPsite3
US 20100203611

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Nanoparticle
Cytoplasm and nucleus
In vitro
CTTTTTTHHHHTTHHHHSSCC
Additional Detail Fields 1 fields
CTTTTTTHHHHTTHHHHSSCC