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Peptide record

TPDB61765

CPP2-p16MIS Cell-penetrating Peptides standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB61765
CPP2-p16MIS
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 27-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with FITC
Sequence
DSLKSYWYLQKFSWRGPGFLDTLVVLH
Physicochemical Analysis
C157H227N37O39
ANCEIM
L
3256.75
9.50
4
2
13
+1
-2.71
-0.107
93.70
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
13980
429.26
7
Residue Composition
number
0
A
1
R
0
N
2
D
0
C
0
E
1
Q
2
G
1
H
0
I
5
L
2
K
0
M
2
F
1
P
3
S
1
T
2
W
2
Y
2
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 2 C: 0 E: 0 Q: 1 G: 2 H: 1 I: 0 L: 5 K: 2 M: 0 F: 2 P: 1 S: 3 T: 1 W: 2 Y: 2 V: 2
Chemical Descriptors
27
C157H227N37O39
3256.75
9.50
+1
-2.71
-0.107
Free
L
Linear
Conjugated with FITC
NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Crc And Hl-7702 Cells

Assay & Model

SW480 cells bearing 4-week-old male mice
SW480 cells bearing 4-week-old male mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
FITC dye
CPP2-p16MIS had higher cytocidal effects than both CPP2 and p16MIS
In vitro and in vivo
CCSCSTHHHHHHHHHTTTHHHHHHHHTTTSCC
Additional Detail Fields 1 fields
CCSCSTHHHHHHHHHTTTHHHHHHHHTTTSCC