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Peptide record

TPDB61764

CPP2 Cell-penetrating Peptides Tumor-homing Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB61764
CPP2
Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP TumorHoPe2.0
standard
No
A 15-aa standard natural multi-activity (Cell-penetrating Peptides and Tumor-homing Peptides) peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
Sequence
DSLKSYWYLQKFSWR
Physicochemical Analysis
C97H135N23O24
ANCEGHIMPTV
S
2007.28
9.97
3
1
7
+2
-2.84
-1.047
52.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
13980
696.47
6
Residue Composition
number
0
A
1
R
0
N
1
D
0
C
0
E
1
Q
0
G
0
H
0
I
2
L
2
K
0
M
1
F
0
P
3
S
0
T
2
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 2 K: 2 M: 0 F: 1 P: 0 S: 3 T: 0 W: 2 Y: 2 V: 0
Chemical Descriptors
15
C97H135N23O24
2007.28
9.97
+2
-2.84
-1.047
Free
L
Linear
Free
N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)O
Evidence Records 3 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Many Human neoplastic cells including HeLa, Lovo, A549, MCF-7,MKN45,HepG2, LNCap, KPK,U2OS, RC-15,RD-ES,H28,K562,U251,NHDF

Assay & Model

NOD-SCID mice model of xenograft human tumour cells
NOD-SCID mice model of xenograft human tumour cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Fluorophore (FITC)
CPP2 was successfully internalized by primary colon adenocarcinoma cells, showed poor penetration into normal fibroblasts
In vitro and in vivo
CCSSCSSCCCCCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Caco-2 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
Thiazole derivatives
In vitro
CTTHHHHHHHHHHHHHHHHHHHHGGGGTTTCC
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Homing
Colon cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Tumour lineage-homing cell-penetrating peptides as anticancer molecular delivery systems
2012
Eisaku Kondo et al. Nat Commun. 2012 Jul 17:3:951.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Lovo cell line, Sw620, Colo320, WiDr
7-week-old NOD-SCID mouse
mRNA display library
CPP2-RI-p16MIS, FITC-CPP2
Additional Detail Fields 4 fields
CPP2-RI-p16MIS, FITC-CPP2
CCSSCSSCCCCCCCC CTTHHHHHHHHHHHHHHHHHHHHGGGGTTTCC
Lovo cell line, Sw620, Colo320, WiDr
7-week-old NOD-SCID mouse