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Peptide record

TPDB61760

DK17M Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB61760
DK17M
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 17-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
DRQIKGGGQNRRMKWKK-NH2
Physicochemical Analysis
C88H152N34O23S1
ACEHLFPSTYV
K
2086.45
12.16
7
1
3
+6
6.84
-2.282
22.94
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
5500
263.61
3
Residue Composition
number
0
A
3
R
1
N
1
D
0
C
0
E
2
Q
3
G
0
H
1
I
0
L
4
K
1
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 1 C: 0 E: 0 Q: 2 G: 3 H: 0 I: 1 L: 0 K: 4 M: 1 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
17
C88H152N34O23S1
2086.45
12.16
+6
6.84
-2.282
Amidation
L
Cationic
Linear
Free
N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Female SJL/Jmice (5-6 week old)
Female SJL/Jmice (5-6 week old)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Alexa Fluor 680 (AF680) near-infrared fluorescent dye
No infrared signals were found with mutated DK17
In vivo
CCCSSSCCCCTTCSSCC
Additional Detail Fields 1 fields
CCCSSSCCCCTTCSSCC