Back to search

Peptide record

TPDB61756

cyclo-(DP)3 Cell-penetrating Peptides standard
6 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB61756
cyclo-(DP)3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 6-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Positively charged nanospheres ((CP)6NS)
Sequence
DPDPDP
Physicochemical Analysis
C27H38N6O13
ARNCEQGHILKMFSTWYV
DP
654.63
2.82
0
3
0
-3
5.04
-2.550
0.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
3
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
3
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 3 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 3 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
6
C27H38N6O13
654.63
2.82
-3
5.04
-2.550
Free
Positively charged nanospheres ((CP)6NS)
L
Cyclic
Free
N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MDA-MB-231 Cells, HCT-116 Cells, And HUVEC Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L
Synthetic
FAM-siRNA
Cytoplasm
No green fluorescence in cells treated with free FAM-siRNA, whereas cells treated with the (CP)6NS-FAM-siRNA complex showed obvious green fluorescence.
In vitro
CCSSSTTSCCSSHHHHHHHSCCC
Additional Detail Fields 1 fields
CCSSSTTSCCSSHHHHHHHSCCC