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Peptide record

TPDB61754

DNP Cell-penetrating Peptides standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB61754
DNP
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 7-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
DNPGNET
Physicochemical Analysis
C28H43N9O15
ARCQHILKMFSWYV
N
745.70
3.01
0
2
0
-2
4.69
-2.386
0.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
0
0.00
3
Residue Composition
number
0
A
0
R
2
N
1
D
0
C
1
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 2 D: 1 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C28H43N9O15
745.70
3.01
-2
4.69
-2.386
Free
L
Cyclic
Free
N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Caco-2 Cells And hCMEC/D3 Cells

Assay & Model

Male ICR mice (mouse intestinal epithelium)
Male ICR mice (mouse intestinal epithelium)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L
Phage Display
M13 phage
The amounts of DNP-phage was 37.4-fold greater than that of control phage at 30 min
Macropinocytosis
In vitro and in vivo
CCSSCCC
Additional Detail Fields 1 fields
CCSSCCC