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Peptide record

TPDB61745

DGSPL Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB61745
DGSPL
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
DGSPLPQKIHPS
Physicochemical Analysis
C56H90N16O18
ARNCEMFTWYV
P
1275.43
7.81
2
1
2
+0
4.51
-1.050
65.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
0
0.00
3
Residue Composition
number
0
A
0
R
0
N
1
D
0
C
0
E
1
Q
1
G
1
H
1
I
1
L
1
K
0
M
0
F
3
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 1 H: 1 I: 1 L: 1 K: 1 M: 0 F: 0 P: 3 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C56H90N16O18
1275.43
7.81
+0
4.51
-1.050
Free
L
Linear
Free
N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Mc3T3-E1 Cell Line, Caco-2 Cells,

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Phage Display
eGFP at C terminus
Moderate uptake compared to the unmodified negative control eGFP in MC3TS-E1 cells but no uptake in Caco-2 cells
In vitro
CCSTHHHHTTCC
Additional Detail Fields 1 fields
CCSTHHHHTTCC