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Peptide record

TPDB61744

ACPP Cell-penetrating Peptides standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB61744
ACPP
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 26-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Conjugated with Cyanine5 (Cy5)
Sequence
DGGDGGDGGDGPLGLAGRRRRRRRRR
Physicochemical Analysis
C108H191N53O35
NCEQHIKMFSTWYV
RG
2792.04
12.30
9
4
3
+5
11.46
-1.935
33.85
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
9
R
0
N
4
D
0
C
0
E
0
Q
9
G
0
H
0
I
2
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 9 N: 0 D: 4 C: 0 E: 0 Q: 0 G: 9 H: 0 I: 0 L: 2 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
26
C108H191N53O35
2792.04
12.30
+5
11.46
-1.935
Conjugated with Cyanine5 (Cy5)
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hct116, Dld1, Km12 And Ncm460 Cells

Assay & Model

Athymic male mice (BALB/c nu/nu, 18-20 g)
Athymic male mice (BALB/c nu/nu, 18-20 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Cy5 dye
Intracellular fluorescence intensity of Cy5 increased over time and is lower in normal cells compared to the colorectal cell lines
Endocytosis
In vitro and in vivo
CCCCCTTC
Additional Detail Fields 1 fields
CCCCCTTC