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Peptide record

TPDB61741

RGD10-10R Cell-penetrating Peptides standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB61741
RGD10-10R
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 23-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
DGARYCRGDCFDGRRRRRRRRRR
Physicochemical Analysis
C117H203N59O31S2
NEQHILKMPSTWV
R
2996.40
12.26
12
3
3
+9
10.72
-2.496
4.35
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
1615
53.90
3
Residue Composition
number
1
A
12
R
0
N
3
D
2
C
0
E
0
Q
3
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 12 N: 0 D: 3 C: 2 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
23
C117H203N59O31S2
2996.40
12.26
+9
10.72
-2.496
Free
L
Cyclic
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MDA-MB-231 Cells,

Assay & Model

MDA-MB-231 xenograft murine model (Male C57BL/6 mice (for in vivo distribution assay, weighing 18–22 g) and female BALB/c nude mice (for tumour-targeting assessment, weighing 18–22 g))
MDA-MB-231 xenograft murine model (Male C57BL/6 mice (for in vivo distribution assay, weighing 18–22 g) and female BALB/c nude mice (for tumour-targeting assessment, weighing 18–22 g))

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Cyclic L
Fusogenic
FAM-labeled siRNA
Cytoplasm
When the molar ratio reached 50:1, the peptide/siRNA complex exhibited transfection efficiency that was equal to that of Lipofectamine 2000, while polyarginine (10R) was unable to deliver siRNA into MDA-MB-231 cells.
Receptor (αvβ3)-mediated endocytosis (RME)
In vitro and in vivo