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Peptide record

TPDB61692

VP22 Cell-penetrating Peptides standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB61692
VP22
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 34-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
DAATATRGRSAASRPTERPRAPARSASRPRRPVD
Physicochemical Analysis
C147H255N61O48
NCQHILKMFWY
R
3645.02
12.50
9
3
9
+6
13.68
-1.356
32.06
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
0
0.00
7
Residue Composition
number
8
A
9
R
0
N
2
D
0
C
1
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
5
P
4
S
3
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 8 R: 9 N: 0 D: 2 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 5 S: 4 T: 3 W: 0 Y: 0 V: 1
Chemical Descriptors
34
C147H255N61O48
3645.02
12.50
+6
13.68
-1.356
Free
L
Linear
Free
N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Eca109 Cells

Assay & Model

Eca109 tumor bearing Female 4- to 6-week-old BALB/c nude mice
Eca109 tumor bearing Female 4- to 6-week-old BALB/c nude mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
PTEN gene at N terminus
pcDNA3-PTEN-VP22 group exhibited a higher level of fluorescence than the pcDNA3-PTEN group
In vitro and in vivo
CCTTCCHHHHTTCCC
Additional Detail Fields 1 fields
CCTTCCHHHHTTCCC