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Peptide record

TPDB61689

P16P1 Cell-penetrating Peptides standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB61689
P16P1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 28-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
DAAREGFLATLVVLHRAGARRRRRRRRR
Physicochemical Analysis
C141H251N63O34
NCQIKMPSWY
R
3372.95
12.83
12
2
11
+9
9.76
-1.057
80.36
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
5
A
11
R
0
N
1
D
0
C
1
E
0
Q
2
G
1
H
0
I
3
L
0
K
0
M
1
F
0
P
0
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 5 R: 11 N: 0 D: 1 C: 0 E: 1 Q: 0 G: 2 H: 1 I: 0 L: 3 K: 0 M: 0 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
28
C141H251N63O34
3372.95
12.83
+9
9.76
-1.057
Free
L
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

451Lu,Wm239A And Wm1158 , Normal Human Dermal Fibroblasts And Two Strains Of Normal Human Melanocytes.

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L
Synthetic
P16P1, cell penetration and wild-type Leu97 in the CDK4-binding site were needed for the toxic and penetration effect in cells.
In vitro