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Peptide record

TPDB61680

Cys-Tat Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB61680
Cys-Tat
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 11-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with FITC
Sequence
CYGRKKRRQRR
Physicochemical Analysis
C61H111N29O14S1
ANDEHILMFPSTWV
R
1506.80
12.24
7
0
1
+7
5.44
-3.000
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
1490
98.89
3
Residue Composition
number
0
A
5
R
0
N
0
D
1
C
0
E
1
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
11
C61H111N29O14S1
1506.80
12.24
+7
5.44
-3.000
Free
L
Cationic
Linear
Conjugated with FITC
N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa , Hbmec E. Coli K1, Salmonella, And Shigella

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
FITC dye and Gentamicin
Cytoplasm
Showed progressive uptake over time
More than one endocytosis pathways and direct translocation
In vitro
CHHHHTTTCC
Additional Detail Fields 1 fields
CHHHHTTTCC