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Peptide record

TPDB61633

Cell-penetrating Peptides standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB61633
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 30-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
CWWRRRRRRRRCRRRRRRRRCRRRRRRRRC
Physicochemical Analysis
C178H330N104O31S4
ANDEQGHILKMFPSTYV
R
4551.50
12.98
24
0
2
+24
14.78
-3.327
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
11250
247.17
4
Residue Composition
number
0
A
24
R
0
N
0
D
4
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 24 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
30
C178H330N104O31S4
4551.50
12.98
+24
14.78
-3.327
Free
L
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Dc2.4 Cells

Assay & Model

Female Balb/c mice of 4-6 weeks
Female Balb/c mice of 4-6 weeks

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Cy5.5 conjugated antigen protein ovalbumin (OVA)
Cytosol
~85% DC2.4 cells internalized peptide/OVA-Cy5.5 higher than that in the OVA alone
In vitro and in vivo
CHHHHHHHHHHHTTBTTBSEEECSSSEEECCGGGC
Additional Detail Fields 1 fields
CHHHHHHHHHHHTTBTTBSEEECSSSEEECCGGGC