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Peptide record

TPDB61630

[(WR)5C] Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB61630
[(WR)5C]
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 11-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Gd nanoparticles
Sequence
CWRWRWRWRWR
Physicochemical Analysis
C88H117N31O12S1
ANDEQGHILKMFPSTYV
RW
1833.16
12.58
5
0
5
+5
-5.44
-2.227
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
27500
1500.14
1
Residue Composition
number
0
A
5
R
0
N
0
D
1
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
5
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 5 Y: 0 V: 0
Chemical Descriptors
11
C88H117N31O12S1
1833.16
12.58
+5
-5.44
-2.227
Free
Gd nanoparticles
L
Cyclic
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CCRF-CEM , MCF-7 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L
Synthetic
Fluorescein-GpYEEI and Epirubicin
the cellular uptake of F-GpYEEI (5 μM) was enhanced by six folds in the presence of [(WR)5C]-GdNPs (50 μM) compared to that of phosphopeptide alone
Energy dependent pathway
In vitro
CCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCC