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Peptide record

TPDB61606

Compound 1 (DCpep-2-NH2) Cell-penetrating Peptides standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB61606
Compound 1 (DCpep-2-NH2)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 14-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Luciferin-linker
Sequence
CVAKYHGYPWCRRR
Physicochemical Analysis
C80H119N27O17S2
NDEQILMFST
R
1795.12
10.09
5
0
5
+4
0.53
-1.079
27.86
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
8605
479.36
4
Residue Composition
number
1
A
3
R
0
N
0
D
2
C
0
E
0
Q
1
G
1
H
0
I
0
L
1
K
0
M
0
F
1
P
0
S
0
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 1 R: 3 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 0 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 2 V: 1
Chemical Descriptors
14
C80H119N27O17S2
1795.12
10.09
+4
0.53
-1.079
Free
Luciferin-linker
L
Cyclic
Free
N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hek293 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L
Synthetic
DOCK2-inhibitory peptide (DCpep-2)
Cytosol
Compounds 2-luc and 5-luc showed higher uptake than 1-luc at all concentrations,
In vitro
CTTSCSSSSCTTC
Additional Detail Fields 1 fields
CTTSCSSSSCTTC