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Peptide record

TPDB61591

6A Cell-penetrating Peptides standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB61591
6A
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 29-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with Alexa Fluor 488
Sequence
CSPQYTIIADAGDFYLHPSYYMLAAAAAA
Physicochemical Analysis
C142H204N32O42S2
RNEKWV
A
3095.49
3.88
1
2
18
-2
-3.15
0.462
81.38
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
5960
192.54
9
Residue Composition
number
8
A
0
R
0
N
2
D
1
C
0
E
1
Q
1
G
1
H
2
I
2
L
0
K
1
M
1
F
2
P
2
S
1
T
0
W
4
Y
0
V
Amino Acid Distribution
A: 8 R: 0 N: 0 D: 2 C: 1 E: 0 Q: 1 G: 1 H: 1 I: 2 L: 2 K: 0 M: 1 F: 1 P: 2 S: 2 T: 1 W: 0 Y: 4 V: 0
Chemical Descriptors
29
C142H204N32O42S2
3095.49
3.88
-2
-3.15
0.462
Free
L
Cationic
Linear
Conjugated with Alexa Fluor 488
N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa And Hacat Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
GFP and Alexa Fluor 488 dye
6A mutation abolished cellular uptake of GFP.
In vitro
CCSSCCSCSSSSSSCSSSCSSCSCC
Additional Detail Fields 1 fields
CCSSCCSCSSSSSSCSSSCSSCSCC