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Peptide record

TPDB61589

CSK Cell-penetrating Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB61589
CSK
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 9-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, and Peptipedia, with an available 3D structural model.
C-terminal: Conjugation to solid lipid nanoparticle
Sequence
CSKSSDYQC
Physicochemical Analysis
C39H61N11O17S2
ARNEGHILMFPTWV
S
1020.10
5.94
1
1
1
-0
1.77
-1.067
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
1615
158.32
7
Residue Composition
number
0
A
0
R
0
N
1
D
2
C
0
E
1
Q
0
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
3
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 2 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 3 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
9
C39H61N11O17S2
1020.10
5.94
-0
1.77
-1.067
Conjugation to solid lipid nanoparticle
L
Linear
Free
N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Caco-2 cells and goblet like HT29-MTX cells

Assay & Model

Male Sprague-Dawley rats
Male Sprague-Dawley rats

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Protein (FITC-sCT), Nanoparticle( SLN)
Showed significantly higher drug internalization than that of unmodified ones
Clathrin- and caveolin-mediated endocytosis
In vitro and in vivo
CCCCSCSCC
Additional Detail Fields 1 fields
CCCCSCSCC