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Peptide record

TPDB61588

C105Y Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB61588
C105Y
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugation with fluorescein/FITC
Sequence
CSIPPEVKFNPFVYLI-NH2
Physicochemical Analysis
C91H136N18O22S1
ARDQGHMTW
P
1866.25
6.28
1
1
8
-0
0.43
0.719
109.38
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
1490
79.84
4
Residue Composition
number
0
A
0
R
1
N
0
D
1
C
1
E
0
Q
0
G
0
H
2
I
1
L
1
K
0
M
2
F
3
P
1
S
0
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 1 E: 1 Q: 0 G: 0 H: 0 I: 2 L: 1 K: 1 M: 0 F: 2 P: 3 S: 1 T: 0 W: 0 Y: 1 V: 2
Chemical Descriptors
16
C91H136N18O22S1
1866.25
6.28
-0
0.43
0.719
Amidation
L
Linear
Conjugation with fluorescein/FITC
N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HuH7, 3T3, and primary HTE cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Fluorophore (fluorescein/ FITC)
Cytoplasm and nucleus, nucleolus
Clathrin- and caveolin-independent lipid raft-mediated endocytic process
In vitro
CCCCSSCSCCCCCCCC
Additional Detail Fields 1 fields
CCCCSSCSCCCCCCCC