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Peptide record

TPDB61584

LYSTAT Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB61584
LYSTAT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Lysosomal targeting sequence
Sequence
CSEWAYGRKKRRQRRR
Physicochemical Analysis
C89H150N38O22S1
NDHILMFPTV
R
2136.47
12.12
8
1
3
+7
6.38
-2.556
6.25
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
6990
327.17
4
Residue Composition
number
1
A
6
R
0
N
0
D
1
C
1
E
1
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
1
S
0
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 6 N: 0 D: 0 C: 1 E: 1 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 1 V: 0
Chemical Descriptors
16
C89H150N38O22S1
2136.47
12.12
+7
6.38
-2.556
Free
Lysosomal targeting sequence
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

B3 And ARPE19 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
FITC-labelled
Cytoplasm and Lysosomes
Like Nicastrin and Penetratin, in TAT Lysosome fluorescence was dimmed in ARPE19, but mostly unaffected in B3 cells
In vitro
CCCSSCC
Additional Detail Fields 1 fields
CCCSSCC