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Peptide record

TPDB61580

[C(WR)4K] Cell-penetrating Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB61580
[C(WR)4K]
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 9-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
CRWRWKWRW
Physicochemical Analysis
C71H95N23O10S1
ANDEQGHILMFPSTYV
W
1462.74
12.12
4
0
4
+4
-4.22
-2.056
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
22000
1504.02
1
Residue Composition
number
0
A
3
R
0
N
0
D
1
C
0
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
9
C71H95N23O10S1
1462.74
12.12
+4
-4.22
-2.056
Free
L
Cyclic
Free
N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hek-293.Skov-3, Ht-1080 And CCRF-CEM Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L
Synthetic
Doxorubicin (Dox)-thiol
Nucleus
Dox-SS-[C(WR)4K] showed a higher cellular uptake in SKOV-3 and HT-1080 cells.
In vitro
CCSSSCCTTTTSCC
Additional Detail Fields 1 fields
CCSSSCCTTTTSCC