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Peptide record

TPDB61573

[R6W3] Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB61573
[R6W3]
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
CRRWWRRWRR
Physicochemical Analysis
C72H109N31O11S1
ANDEQGHILKMFPSTYV
R
1616.92
12.70
6
0
3
+6
-0.93
-2.720
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
16500
1020.46
1
Residue Composition
number
0
A
6
R
0
N
0
D
1
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
10
C72H109N31O11S1
1616.92
12.70
+6
-0.93
-2.720
Free
L
Cationic and amphipathic
Cyclic
Free
N[C@@H](CS)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO-K1, CHO-Pgsa745

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L Cationic and amphipathic
Synthetic
Protein kinase C inhibitor (PKCi)
Cytoplasm
Highest among the classical cyclic CPP
GAG-dependent endocytosis and Direct translocation
In vitro
CCCTTTTTTSCCC
Additional Detail Fields 1 fields
CCCTTTTTTSCCC